Inhibition of Hepatic-induced Enzyme Formation by 8-Azaguanine
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چکیده
منابع مشابه
Inhibition of hepatic-induced enzyme formation by 8-azaguanine.
A body of evidence has accumulated which indicates that the :purine analogue, 8-azaguanine, has an inhibitory action upon protein synthesis. It has been shown in several laboratories that the production of certain inducible bacterial enzymes may be inhibited by this agent (14). It has also been reported by Mandel (5) that utilization of methionine-Ss5 and cystine-S35 for protein synthesis was m...
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The biochemical mechanism underlying the cytotoxic and carcinostatic (l-3) effects of 8-axaguanine is still uncertain. Current hypotheses are that the compound acts directly as a metabolite antagonist to guanine utilization (4) or that it is incorporated into nucleic acids and that these fraudulent nucleic acids serve as the active pharmacological agents (5-7). An alternative hypothesis being e...
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For many years, 8-azaguanine (1) has received much attention because of its remarkable biological activity''. In 1961, this compound was found to be a metabolite of Streptomyces albus var. pathocidicus and named pathocidin2'. The same strain also produces a cytosine nucleoside antibiotic, blasticidin S. Because it is an example of an unusual nucleobase occurring in nature, we became interested ...
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Female mice of the Japanese dd strain were mated at 3 to 5 months of age. On days 7 to 15 of pregnancy they were given a single intraperitoneal injection of 8-azaguanine solution (16 mg. /c.c.) and then were sacrificed shortly before term to determine state of pregnancy and condition of the foetuses. Routine histological examinations were made of malformed organs and also of the placentae of af...
متن کاملThe assimilation of amino acids by bacteria. 22. The effect of 8-azaguanine upon enzyme formation in Staphylococcus aureus.
Balmain, J. H., Folley, S. J. & Glascock, R. F. (1952). Biochem. J. 52, 301. Berger, L., Slein, M. W., Colowick, S. P. & Cori, C. F. (1946). J. gen. Physiol. 28, 379. Brady, R. 0. & Gurin, S. (1952). J. biol. Chem. 199, 421. Korkes, S., del Campillo, A., Gunsalus, I. C. & Ochoa, S. (1951). J. biol. Chem. 193, 721. Krebs, H. A. & Eggleston, L. V. (1945). Biochem. J. 39, 408. Meyerhof, 0. (1927)....
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1960
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)64558-2